Adapalene Gel Effective Against Acne
Adapalene gel 0.3% is safe and effective for the treatment of acne
vulgaris, results of a study published in the Journal of the American
Academy of Dermatology suggest.
Researchers compared the safety and efficacy of adapalene gel 0.3%, adapalene gel 0.1%, and gel vehicle.
A total of 653 acne patients at least 12 years of age with 20 to 100
noninflammatory acne lesions, 20 to 50 inflammatory acne lesions, and
no nodules or cysts were included.
The primary efficacy measures
were success rate -- percent of patients rated "clear" or "almost
clear" on the Investigators Global Assessment (IGA) -- and the percent
acne lesion reduction from baseline for total, inflammatory, and
The researchers, led by Dr. Michael Graeber, of Galderma Research
and Development, Cranbury, New Jersey, report that adapalene gel 0.3%
was significantly superior to the other two treatments in success rate,
total lesion count, and inflammatory acne lesion count.
Treatment-related adverse events were reported by 22% of patients in
the adapalene gel 0.3% group, 12% of those in the adapalene gel 0.1%
group, and 4.5% of those in the vehicle gel group.
The most common side effect were dry skin and skin discomfort.
Patients in both adapalene gel treatment groups had a similar
incidence of erythema. Erythema, scaling, dryness, and stinging/burning
were mostly mild or moderate and were transient in duration.
"The results of this study have implications for the management of acne vulgaris," the authors write.